{"success":true,"data":{"id":175,"title":"NSCLC | 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30\/50\u57fa\u56e0\u8fd8\u53ef\u4ee5\u68c0\u6d4b\u7532\u72b6\u817a\u764c\u7b49\u3002\u672c\u516c\u53f8\u5b89\u660e\u5eb7\u00ae\u7cfb\u5217\u91c7\u7528RNA-NGS\u6d4b\u5e8f\u6280\u672f\uff0c\u5b89\u53f8\u5eb7\u00ae\u548c\u5b89\u62e9\u5eb7\u00ae\u7cfb\u5217\u91c7\u7528DNA-NGS\u6d4b\u5e8f\u6280\u672f\uff0c\u53ef\u5168\u9762\u68c0\u6d4b\u591a\u79cdALK\u878d\u5408\u7c7b\u578b\uff0c\u8bc4\u4f30\u5305\u62ecALK-TKI\u5728\u5185\u7684\u591a\u79cd\u9776\u5411\u3001\u514d\u75ab\u53ca\u5316\u7597\u836f\u7269\u7684\u7597\u6548\uff0c\u6307\u5bfc\u4e34\u5e8a\u7cbe\u51c6\u7528\u836f\uff0c\u6539\u5584\u80bf\u7624\u60a3\u8005\u7684\u9884\u540e\uff0c\u63d0\u9ad8\u5176\u751f\u6d3b\u8d28\u91cf\uff0c\u5ef6\u957f\u751f\u5b58\u671f\u3002\u53c2\u8003\u6587\u732e [1] Morris SW, Kirstein MN, Valentine MB et al. Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma. Science. 1994;263(5151):1281-4. [2]Barreca A, Lasorsa E, Riera L et al. Anaplastic lymphoma kinase in human cancer. J Mol Endocrinol 2011; 47: R11\u201323. [3]Franco R, Rocco G, Marino FZ et al. Anaplastic lymphoma kinase: A glimmer of hope in lung cancer treatment? Expert Rev Anticancer Ther 2013; 13: 407\u201320. [4]Pikor LA, Ramnarine VR, Lam S et al. Genetic alterations defining NSCLC subtypes and their therapeutic implications. Lung Cancer 2013;82:179. [5]Choi YL, Takeuchi K, Soda M et al. Identification of novel isoforms of the EML4-ALK transforming gene in non-small cell lung cancer. Cancer Res 2008; 68: 4971\u20136. [6]Li TH, Maus MK, Desai SJ et al. Large-scale screening and molecular characterization of EML4-ALK fusion variants in archival non-small-cell lung cancer tumor specimens using quantitative reverse transcription polymerase chain reaction assays. J Thorac Oncol 2014; 9:18-25. [7]Kelly LM, Barila G, Liu P, et al. Identification of the transforming STRN-ALK fusion as a potential therapeutic target in the aggressive forms of thyroid cancer[J]. Proc Natl Acad Sci, 2014, 111(11):4233-4238. [8]Kohno T, Nakaoku T, Tsuta K, et al. Beyond ALK-RET, ROS1 and other oncogene fusion in lung cancer. Transl Lung Cancer Res[J]. 2015;4(2):156-164. [9]Shaw AT, Kim DW, Nakagawa K, et al. Crizotinib versus chemotherapy in advanced ALK-positive lung cancer[J]. N Engl J Med. 2013;368(25):2385-2394. [10]Solomon BJ, Kim DW, Wu YL, et al. Final Overall Survival Analysis From a Study Comparing First-Line Crizotinib Versus Chemotherapy in ALK-Mutation-Positive Non-Small-Cell Lung Cancer[J]. J Clin Oncol. 2018;36(22):2251-2258. [11]Daniel Tan et al. 2019 ESMO,1473P. [12]Camidge DR, Dziadziuszko R, Peters S, et al. Updated Efficacy and Safety Data and Impact of the EML4-ALK Fusion Variant on the Efficacy of Alectinib in Untreated ALK-Positive Advanced Non-Small Cell Lung Cancer in the Global Phase III ALEX Study [published correction appears in J Thorac Oncol. 2019 Nov;14(11):2023][J]. J Thorac Oncol. 2019;14(7):1233-1243. [13]Peters S, Camidge DR, Shaw AT, et al. Alectinib versus Crizotinib in Untreated ALK-Positive Non-Small-Cell Lung Cancer[J]. N Engl J Med. 2017;377(9):829-838. [14]Camidge DR, Kim HR, Ahn MJ, et al. Brigatinib Versus Crizotinib in Advanced ALK Inhibitor-Naive ALK-Positive Non-Small Cell Lung Cancer: Second Interim Analysis of the Phase III ALTA-1L Trial[J]. J Clin Oncol. 2020;38(31):3592-3603. [15]Solomon B, Bauer TM, De Marinis F, et al. LBA2 Lorlatinib vs crizotinib in the first-line treatment of patients (pts) with advanced ALK-positive non-small cell lung cancer(NSCLC): Results of the phase III CROWN study[J]. 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