{"success":true,"data":{"id":176,"title":"\u4ece\u6307\u5357\u5171\u8bc6\u770bEGFR-TKI\u5728\u65e9\u4e2d\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u8f85\u52a9\u6cbb\u7597\u4e2d\u7684\u5e94\u7528","summary":"\u672c\u6587\u7cfb\u7edf\u7efc\u8ff0\u4e86EGFR-TKI\u5728\u65e9\u4e2d\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u672f\u540e\u8f85\u52a9\u6cbb\u7597\u4e2d\u7684\u5e94\u7528\u3002\u6587\u7ae0\u6307\u51fa\uff0c\u9488\u5bf9EGFR\u7a81\u53d8\u9633\u6027\u60a3\u8005\uff0c\u591a\u9879\u7814\u7a76\u8bc1\u5b9eEGFR-TKI\u8f85\u52a9\u6cbb\u7597\u80fd\u663e\u8457\u5ef6\u957f\u65e0\u75c5\u751f\u5b58\u671f\uff0c\u964d\u4f4e\u590d\u53d1\u98ce\u9669\u3002\u5965\u5e0c\u66ff\u5c3c\u3001\u57c3\u514b\u66ff\u5c3c\u3001\u5409\u975e\u66ff\u5c3c\u7b49\u836f\u7269\u5df2\u83b7\u56fd\u5185\u5916\u6307\u5357\u63a8\u8350\u3002\u6587\u7ae0\u8be6\u7ec6\u89e3\u8bfb\u4e86ADAURA\u3001ADJUVANT\u7b49\u5173\u952e\u4e34\u5e8a\u7814\u7a76\u6570\u636e\uff0c\u5bf9\u6bd4\u4e86\u4e0d\u540c\u836f\u7269\u7684\u7597\u6548\u4e0e\u9002\u5e94\u8bc1\uff0c\u5e76\u4f9d\u636eCSCO\u3001NCCN\u7b49\u6700\u65b0\u6307\u5357\uff0c\u660e\u786e\u4e86\u4e0d\u540c\u5206\u671f\u60a3\u8005\u7684\u6cbb\u7597\u63a8\u8350\u3001\u7528\u836f\u65f6\u957f\u53ca\u68c0\u6d4b\u5fc5\u8981\u6027\u3002","highlights":["EGFR\u7a81\u53d8\u9633\u6027\u65e9\u4e2d\u671fNSCLC\u60a3\u8005\u672f\u540e\u8f85\u52a9\u4f7f\u7528EGFR-TKI\uff08\u5982\u5965\u5e0c\u66ff\u5c3c\u3001\u57c3\u514b\u66ff\u5c3c\uff09\u53ef\u663e\u8457\u5ef6\u957fDFS\uff0c\u964d\u4f4e\u590d\u53d1\u4e0e\u6b7b\u4ea1\u98ce\u9669\u3002","\u591a\u9879\u5173\u952e\u7814\u7a76\uff08ADAURA\u3001ADJUVANT\u3001EVIDENCE\u3001EVAN\uff09\u4e3aEGFR-TKI\u8f85\u52a9\u6cbb\u7597\u63d0\u4f9b\u4e86\u9ad8\u7ea7\u522b\u5faa\u8bc1\u533b\u5b66\u8bc1\u636e\u3002","\u56fd\u5185\u5916\u6307\u5357\uff08CSCO\u3001NCCN\uff09\u5df2\u660e\u786e\u63a8\u8350\u5965\u5e0c\u66ff\u5c3c\u7b49EGFR-TKI\u7528\u4e8eIB-IIIA\u671fEGFR\u7a81\u53d8\u60a3\u8005\u672f\u540e\u8f85\u52a9\u6cbb\u7597\u3002","\u672f\u540e\u8f85\u52a9\u9776\u5411\u6cbb\u7597\u65f6\u957f\u901a\u5e38\u5efa\u8bae\u4e3a2-3\u5e74\uff0c\u6cbb\u7597\u524d\u9700\u8fdb\u884cEGFR\u7b49\u57fa\u56e0\u68c0\u6d4b\u4ee5\u6307\u5bfc\u7cbe\u51c6\u7528\u836f\u3002"],"faq":[{"question":"\u8fd9\u7bc7\u6587\u7ae0\u8ba8\u8bba\u4e86\u54ea\u4e9b\u4e3b\u9898\uff1f","answer":"EGFR-TKI,\u975e\u5c0f\u7ec6\u80de\u80ba\u764c,\u8f85\u52a9\u6cbb\u7597,\u6307\u5357\u5171\u8bc6,\u4e34\u5e8a\u7814\u7a76,\u5965\u5e0c\u66ff\u5c3c,\u9776\u5411\u6cbb\u7597,\u65e0\u75c5\u751f\u5b58\u671f,\u57fa\u56e0\u68c0\u6d4b,\u672f\u540e\u590d\u53d1"},{"question":"\u6587\u7ae0\u6838\u5fc3\u89c2\u70b9\u662f\u4ec0\u4e48\uff1f","answer":"\u80ba\u764c\u6700\u5e38\u89c1\u7684\u75c5\u7406\u7c7b\u578b\u4e3a\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\uff0c\u7ea6\u5360\u6240\u6709\u80ba\u764c\u768485%\u3002\u6839\u636e\u7b2c\u516b\u7248AJCC\u764c\u75c7\u5206\u671f\u624b\u518c\uff08\u6700\u65b0\u7248\uff09\uff0c\u5927\u7ea620%~30%\u7684\u60a3\u8005\u521d\u8bca\u65f6\u4e3a\u65e9\u671f\u9636\u6bb5\uff08I-IIIA\uff09\uff0c\u5e76\u4e14\u53ef\u80fd\u9002\u5408\u624b\u672f\u5207\u9664\u4ee5\u8fbe\u5230\u6cbb\u6108\u76ee\u7684\u3002\u8f85\u52a9\u5316\u7597\u662f\u6839\u6cbb\u6027\u624b\u672f\u540eIB\u671f\uff08\u80bf\u7624\u22654cm\uff09\u81f3III\u671f\uff08\u7b2c\u4e03\u7248AJCC\u764c\u75c7\u5206\u671f\u624b\u518c\uff09\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u6807\u51c6\u6cbb\u7597\u65b9\u6848\u3002\u7136\u800c\uff0c\u6839\u636eAJCC\u7b2c\u516b\u7248\u7684\u6570\u636e\uff0c\u8d85\u8fc7\u4e00\u534a\u7684\u6709\u6cbb\u6108\u76ee\u7684\u7684\u60a3\u8005\u57285\u5e74\u5185\u7ecf\u5386\u4e86\u764c\u75c7\u590d\u53d1"}],"keywords":"EGFR-TKI,\u975e\u5c0f\u7ec6\u80de\u80ba\u764c,\u8f85\u52a9\u6cbb\u7597,\u6307\u5357\u5171\u8bc6,\u4e34\u5e8a\u7814\u7a76,\u5965\u5e0c\u66ff\u5c3c,\u9776\u5411\u6cbb\u7597,\u65e0\u75c5\u751f\u5b58\u671f,\u57fa\u56e0\u68c0\u6d4b,\u672f\u540e\u590d\u53d1","content":"\u80ba\u764c\u6700\u5e38\u89c1\u7684\u75c5\u7406\u7c7b\u578b\u4e3a\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\uff0c\u7ea6\u5360\u6240\u6709\u80ba\u764c\u768485%\u3002\u6839\u636e\u7b2c\u516b\u7248AJCC\u764c\u75c7\u5206\u671f\u624b\u518c\uff08\u6700\u65b0\u7248\uff09\uff0c\u5927\u7ea620%~30%\u7684\u60a3\u8005\u521d\u8bca\u65f6\u4e3a\u65e9\u671f\u9636\u6bb5\uff08I-IIIA\uff09\uff0c\u5e76\u4e14\u53ef\u80fd\u9002\u5408\u624b\u672f\u5207\u9664\u4ee5\u8fbe\u5230\u6cbb\u6108\u76ee\u7684\u3002\u8f85\u52a9\u5316\u7597\u662f\u6839\u6cbb\u6027\u624b\u672f\u540eIB\u671f\uff08\u80bf\u7624\u22654cm\uff09\u81f3III\u671f\uff08\u7b2c\u4e03\u7248AJCC\u764c\u75c7\u5206\u671f\u624b\u518c\uff09\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u6807\u51c6\u6cbb\u7597\u65b9\u6848\u3002\u7136\u800c\uff0c\u6839\u636eAJCC\u7b2c\u516b\u7248\u7684\u6570\u636e\uff0c\u8d85\u8fc7\u4e00\u534a\u7684\u6709\u6cbb\u6108\u76ee\u7684\u7684\u60a3\u8005\u57285\u5e74\u5185\u7ecf\u5386\u4e86\u764c\u75c7\u590d\u53d1\uff0c5\u5e74\u603b\u751f\u5b58\u7387\uff08OS\uff09\u4ecd\u7136\u5f88\u4f4e\uff0cII\u671f\u4e3a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\u6709\u7814\u7a76\u663e\u793a\u4e9a\u88d4\u65e9\u4e2d\u671f\u80ba\u817a\u764c\u60a3\u8005\u4e2dEGFR\u7a81\u53d8\u9633\u6027\u7387\u4e0e\u665a\u671f\u76f8\u4f3c\uff0c\u5747\u4e3a50%\u5de6\u53f3\uff0c\u5176\u4e2d\u5e38\u89c1\u7684EGFR\u654f\u611f\u7a81\u53d8\u5305\u62ec19\u53f7\u5916\u663e\u5b50\u7f3a\u5931\uff0819del\uff09\u548c21\u53f7\u5916\u663e\u5b50L858R\u70b9\u7a81\u53d8\uff0c\u5728\u6240\u6709EGFR\u7a81\u53d8\u4e2d\u7ea6\u536090%\u3002\u5728\u4e2d\u56fd\u8fdb\u884c\u7684ICAN\u7814\u7a76\u4e2d\uff0c\u5206\u522b\u5728\u672f\u540eIA\u671f\u3001IB\u671f\u3001II\u671f\u548cIIIA\u671f\u60a3\u8005\u4e2d\u89c2\u5bdf\u523063.2%\u300155.4%\u300154.1%\u548c48.5%\u7684EGFR\u6539\u53d8\u3002 \u25b2\u65e9\u4e2d\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764cEGFR\u7a81\u53d8\u7387\uff08ICAN\u7814\u7a76\uff09 EGFR-TKIs\u672f\u540e\u8f85\u52a9\u6cbb\u7597\u7684\u4e34\u5e8a\u7814\u7a76 EGFR-TKI\u8f85\u52a9\u6cbb\u7597\u8fdb\u884c\u4e86\u5e7f\u6cdb\u7684\u63a2\u7d22\u3002BR19\u4ee5\u53caRADIANT\u7814\u7a76\u5747\u63a2\u7d22\u4e86TKI\u5728EGFR\u7a81\u53d8\u975e\u9009\u62e9\u4eba\u7fa4\u4e2d\u7684\u672f\u540e\u8f85\u52a9\u6cbb\u7597\u4ef7\u503c\uff0c\u5747\u4ee5\u5931\u8d25\u544a\u7ec8\u3002\u53e6\u56db\u9879\u9488\u5bf9EGFR\u7a81\u53d8\u578bNSCLC\u60a3\u8005\u672f\u540e\u7ed9\u4e88EGFR-TKI\u6cbb\u7597\u7684\u7814\u7a76\uff08ADJUVANT\u3001EVAN\u3001EVIDENCE\u548cADAURA\u7814\u7a76\uff09\u8bc1\u5b9e\u4e86\u9776\u5411\u6cbb\u7597\u4f5c\u4e3a\u8f85\u52a9\u6cbb\u7597\u7684\u53ef\u884c\u6027\u3002 ADJUVANT\u7814\u7a76 ADJUVANT\u7814\u7a76\uff08CTONG1104\uff09\u662f\u9996\u4e2a\u5728EGFR\u7a81\u53d8\u9633\u6027\u3001\u5b8c\u5168\u5207\u9664\u7684\u75c5\u7406II~IIIA\u671f\uff08N1-2\uff09\u7684NSCLC\u60a3\u8005\u4e2d\uff0c\u6bd4\u8f83\u4e86\u5409\u975e\u66ff\u5c3c\u5bf9\u6bd4\u957f\u6625\u745e\u6ee8+\u987a\u94c2\u65b9\u6848\u7684\u524d\u77bb\u6027\u968f\u673a\u3001\u5bf9\u7167III\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5171\u5165\u7ec4 222\u4f8b\u60a3\u8005\u3002\u6700\u7ec8\u6570\u636e\u5206\u6790\u663e\u793a\uff0c\u4e0e\u5316\u7597\u76f8\u6bd4\uff0c\u5409\u975e\u66ff\u5c3c\u663e\u8457\u5ef6\u957f\u4e86\u4e2d\u4f4d\u65e0\u75c5\u751f\u5b58\u65f6\u95f4\uff08DFS\uff09\uff0830.8\u4e2a\u6708 vs. 19.8\u4e2a\u6708, HR\uff1a0.56, P=0.001\uff09\uff0c\u4f46\u672a\u663e\u8457\u5ef6\u957f\u4e2d\u4f4dOS\uff1b\u4e9a\u7ec4\u5206\u6790\u663e\u793a\uff0cN2\u60a3\u8005\u7684DFS\u83b7\u76ca\u66f4\u591a\u3002\u7814\u7a76\u663e\u793a\uff0cEGFR\u7a81\u53d8\u9633\u6027II~IIIA\u671fNSCLC\u60a3\u8005\u672f\u540e\u4f7f\u7528\u5409\u975e\u66ff\u5c3c\u6cbb\u75972\u5e74\u80fd\u591f\u964d\u4f4e\u75be\u75c5\u590d\u53d1\u6216\u6b7b\u4ea1\u98ce\u966944%\uff0c\u4e14\u4e2d\u4f4dOS\u957f\u8fbe75.5\u4e2a\u6708\u3002 EVIDENCE\u7814\u7a76 EVIDENCE\u7814\u7a76\u662f\u9996\u4e2a\u56fd\u4ea7\u539f\u7814EGFR-TKI\u5f00\u5c55\u7684\u591a\u4e2d\u5fc3\u3001\u968f\u673a\u3001\u5f00\u653e\u6807\u7b7e\u7684III\u671f\u4e34\u5e8a\u7814\u7a76\uff0c\u5bf9\u6bd4\u57c3\u514b\u66ff\u5c3c\u4e0e\u6807\u51c6\u8f85\u52a9\u5316\u7597\u5728II~IIIA\u671f\u4f34EGFR\u7a81\u53d8NSCLC\u5b8c\u5168\u5207\u9664\u672f\u540e\u8f85\u52a9\u6cbb\u7597\u7684\u7597\u6548\u4e0e\u5b89\u5168\u6027\uff0c\u5171\u5165\u7ec4322\u4f8b\u60a3\u8005\u3002\u4e0e\u6807\u51c6\u5316\u7597\u76f8\u6bd4\uff0c\u57c3\u514b\u66ff\u5c3c\u663e\u8457\u63d0\u9ad83\u5e74DFS\u7387\uff0863.88% vs. 32.47%\uff0cP<0.001\uff09\u53ca\u663e\u8457\u5ef6\u957f\u4e2d\u4f4dDFS\uff0847.0\u4e2a\u6708 vs. 22.1\u4e2a\u6708\uff0cHR\uff1a0.36\uff0cP<0.0001\uff09\uff0c\u964d\u4f4e\u75be\u75c5\u590d\u53d1\u6216\u6b7b\u4ea1\u98ce\u966964%\u3002\u7814\u7a76\u8868\u660e\uff0c\u57c3\u514b\u66ff\u5c3c\u672f\u540e\u8f85\u52a9\u7597\u6548\u660e\u663e\u4f18\u4e8e\u6807\u51c6\u8f85\u52a9\u5316\u7597\uff0c\u5ef6\u957f\u4e86\u60a3\u8005\u7684DFS\uff0c\u4e14\u5b89\u5168\u6027\u66f4\u4f18\u3002\u57fa\u4e8e\u6b64\u7814\u7a76\u7ed3\u679c\uff0c\u57c3\u514b\u66ff\u5c3c\u83b7\u6279\u7528\u4e8eII~IIIA\u671fEGFR\u654f\u611f\u7a81\u53d8NSCLC\u672f\u540e\u8f85\u52a9\u6cbb\u7597\u9002\u5e94\u8bc1\u3002 EVAN\u7814\u7a76 EVAN\u7814\u7a76\u662f\u6bd4\u8f83\u5384\u6d1b\u66ff\u5c3c\u4e0eNP\u5316\u7597\uff08\u957f\u6625\u65b0\u78b1+\u987a\u94c2\uff09\u4f5c\u4e3aIIIA\u671fEGFR\u7a81\u53d8NSCLC\u60a3\u8005\u7684\u8f85\u52a9\u6cbb\u7597\u7597\u6548\u4e0e\u5b89\u5168\u6027\u7684\u56fd\u5185\u591a\u4e2d\u5fc3\u968f\u673aII\u671f\u7814\u7a76\u3002\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0c\u4e0e\u5316\u7597\u7ec4\u76f8\u6bd4\uff0c\u5384\u6d1b\u66ff\u5c3c\u7ec4\u7597\u6548\u66f4\u4f18\uff0c2\u5e74DFS\u7387\u663e\u8457\u63d0\u9ad8\uff0881.4% vs. 44.6%\uff0cP=0.0054\uff0cHR\uff1a0.268\uff09\uff0c\u964d\u4f4e\u75be\u75c5\u590d\u53d1\u6216\u6b7b\u4ea1\u98ce\u966973%\u3002\u968f\u8bbf43\u4e2a\u6708\u7684\u66f4\u65b0\u6570\u636e\u663e\u793a\uff0c\u4e0eNP\u5316\u7597\u65b9\u6848\u76f8\u6bd4\uff0c\u672f\u540e\u8f85\u52a9\u5384\u6d1b\u66ff\u5c3c\u7ec4\u663e\u8457\u6539\u5584\u4e86IIIA\u671fEGFR\u9633\u6027NSCLC\u60a3\u8005\u7684OS\u548c5\u5e74\u6cbb\u6108\u7387\uff0c\u4e24\u7ec4\u7684\u4e2d\u4f4dOS\u4e3a84.2\u548c61.1\u4e2a\u6708\uff0c5\u5e74OS\u7387\u5206\u522b\u4e3a84.8%\u548c51.1%\u3002 ADAURA\u7814\u7a76 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2023.V4\u7248\u975e\u5c0f\u7ec6\u80de\u80ba\u764cNCCN\u6307\u5357\u6307\u51fa\uff1a\u5bf9\u4e8e\u5b8c\u5168\u5207\u9664\u7684\u9ad8\u98ce\u9669IB\u671f\uff08T2a\uff0cN0\uff09\u81f3IIIB\uff08T3\uff0cN2\uff09\u671f\u643a\u5e26EGFR 19\u53f7\u5916\u663e\u5b50\u7f3a\u5931\u621621\u53f7\u5916\u663e\u5b50L858R\u7684NSCLC\u60a3\u8005\uff0c\u5148\u524d\u63a5\u53d7\u8fc7\u8f85\u52a9\u5316\u7597\u6216\u4e0d\u9002\u5408\u63a5\u53d7\u94c2\u7c7b\u5316\u7597\uff0c\u63a8\u8350\u4f7f\u7528\u5965\u5e0c\u66ff\u5c3c\u4f5c\u4e3a\u8f85\u52a9\u6cbb\u7597\u9009\u62e9\u3002\u57282023\u5e74\u7684\u66f4\u65b0\u7248\uff08V1\u7248\uff09\u4e2d\uff0cNCCN\u4e13\u5bb6\u7ec4\u6839\u636eAJCC\u5206\u671f\u7cfb\u7edf\u7b2c7\u7248\u548c\u7b2c8\u7248\u4e4b\u95f4\u7684\u5dee\u5f02\uff0c\u6269\u5927\u4e86\u9002\u7528\u7684\u5206\u671f\u6807\u51c6\uff0c\u5c06IIIB\u671f\uff08T3\uff0cN2\uff09 NSCLC\u60a3\u8005\u7eb3\u5165\u5176\u4e2d\u3002\u867d\u7136\u76ee\u524d\u4f7f\u7528\u7684\u662fAJCC\u5206\u671f\u624b\u518c\u7684\u7b2c8\u7248\uff0c\u4f46\u4e34\u5e8a\u8bd5\u9a8c\u4f7f\u7528\u7684\u662f\u7b2c7\u7248\u3002\u25b22023.V4\u7248NCCN\u6307\u5357\u63a8\u8350\u5965\u5e0c\u66ff\u5c3c\u7528\u4e8eEGFR\u654f\u611f\u7a81\u53d8\u60a3\u8005\u672f\u540e\u8f85\u52a9\u6cbb\u7597 \u300aI~IIIB\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u5b8c\u5168\u5207\u9664\u672f\u540e\u8f85\u52a9\u6cbb\u7597\u6307\u5357\uff082021\u7248\uff09\u300b\uff08\u4ee5\u4e0b\u7b80\u79f0\uff1a\u300a2021\u7248\u6307\u5357\u300b\uff09\u4e2d\u9488\u5bf9EGFR\u7a81\u53d8\u9633\u6027\u7684I~IIIB\u671fNSCLC\u80bf\u7624\u5b8c\u5168\u5207\u9664\u672f\u540e\u8f85\u52a9\u6cbb\u7597\u7684\u63a8\u8350\u610f\u89c1\u5982\u4e0b\uff1a 1. EGFR\u7a81\u53d8\u9633\u6027\u7684IA\u671fNSCLC\u60a3\u8005\u80bf\u7624\u5b8c\u5168\u5207\u9664\u672f\u540e\u5b9a\u671f\u968f\u8bbf\uff0c\u4e0d\u63a8\u8350\u8fdb\u884c\u8f85\u52a9\u5316\u7597\uff081\u7c7b\u8bc1\u636e\uff0c\u63a8\u8350\uff09\u3002 2. EGFR\u7a81\u53d8\u9633\u6027\u7684IB\u671fNSCLC\u60a3\u8005\u80bf\u7624\u5b8c\u5168\u5207\u9664\u672f\u540e\uff0c\u53ef\u8003\u8651\u5e94\u7528\u5965\u5e0c\u66ff\u5c3c\u8f85\u52a9\u6cbb\u7597\uff081A\u7c7b\u8bc1\u636e\uff0c\u63a8\u8350\uff09\u3002 3. EGFR\u7a81\u53d8\u9633\u6027\u7684IIA\u3001IIB\u671fNSCLC\u60a3\u8005\uff0c\u80bf\u7624\u5b8c\u5168\u5207\u9664\u672f\u540e\u63a8\u8350EGFR-TKI[\u5967\u5e0c\u66ff\u5c3c\uff081A\u7c7b\u8bc1\u636e\uff09\uff0c\u5409\u975e\u66ff\u5c3c\uff081B\u7c7b\u8bc1\u636e\uff09\u6216\u57c3\u514b\u66ff\u5c3c\uff081B\u7c7b\u8bc1\u636e\uff09]\u8f85\u52a9\u6cbb\u7597\uff08\u4e00\u81f4\u63a8\u8350\uff09\u3002 4. EGFR\u7a81\u53d8\u9633\u6027\u7684IIIA\u3001IIIB\u671fNSCLC\u60a3\u8005\uff0c\u80bf\u7624\u5b8c\u5168\u5207\u9664\u672f\u540e\u63a8\u8350EGFR-TKI[\u5965\u5e0c\u66ff\u5c3c(1A\u7c7b\u8bc1\u636e)\uff0c\u5409\u975e\u66ff\u5c3c\uff081B\u7c7b\u8bc1\u636e\uff09\uff0c\u57c3\u514b\u66ff\u5c3c\uff081B\u7c7b\u8bc1\u636e\uff09\u6216\u5384\u6d1b\u66ff\u5c3c\uff082\u7c7b\u8bc1\u636e\uff09]\u8f85\u52a9\u6cbb\u7597\uff0c\u4e14\u4f18\u5148\u63a8\u8350\u5965\u5e0c\u66ff\u5c3c\u8f85\u52a9\u6cbb\u7597\uff08\u4e00\u81f4\u63a8\u8350\uff09\u3002 \u300a\u57c3\u514b\u66ff\u5c3c\u672f\u540e\u8f85\u52a9\u6cbb\u7597\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u4e13\u5bb6\u5171\u8bc6\u300b\uff08\u4ee5\u4e0b\u7b80\u79f0\uff1a\u57c3\u514b\u66ff\u5c3c\u5171\u8bc6\uff09\u4e2d\u7684\u4e13\u5bb6\u5171\u8bc61\u610f\u89c1\u6307\u51fa\uff1a\u57c3\u514b\u66ff\u5c3c\u53ef\u4f5c\u4e3aII~IIIA\u671fEGFR\u7a81\u53d8NSCLC\u672f\u540e\u8f85\u52a9\u6cbb\u7597\u7684\u4f18\u5148\u9009\u62e9\u3002\u4f5c\u4e3a\u552f\u4e00\u4e00\u4e2a\u81ea\u4e3b\u77e5\u8bc6\u4ea7\u6743\u7684\u56fd\u4ea7\u7b2c\u4e00\u4ee3EGFR-TKI\uff0c\u57c3\u514b\u66ff\u5c3c\u4e8e2021\u5e74\u83b7\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u6b63\u5f0f\u6279\u51c6\u7528\u4e8eEGFR\u654f\u611f\u7a81\u53d8II~IIIA\u671fNSCLC\u672f\u540e\u8f85\u52a9\u6cbb\u7597\uff0c\u5e76\u4e8e\u540c\u5e74\uff0c\u7ecf\u56fd\u5bb6\u533b\u4fdd\u8c08\u5224\u6b63\u5f0f\u6210\u4e3a\u672f\u540e\u8f85\u52a9\u9776\u5411\u6cbb\u7597\u9886\u57df\u552f\u4e00\u533b\u4fdd\u7528\u836f\uff0c\u836f\u7269\u7684\u7ecf\u6d4e\u6027\u4e0e\u53ef\u53ca\u6027\u5927\u5e45\u63d0\u5347\u3002\u4e13\u5bb6\u5171\u8bc62\u610f\u89c1\u6307\u51fa\uff1a\u63a8\u8350IB\u671fEGFR\u654f\u611f\u7a81\u53d8\u548c\uff08\u6216)\u5408\u5e76\u9ad8\u5371\u56e0\u7d20\u7684\u4eba\u7fa4\u63a5\u53d7\u57c3\u514b\u66ff\u5c3c\u672f\u540e\u8f85\u52a9\u6cbb\u7597\u3002EGFR\u57fa\u56e0\u654f\u611f\u7a81\u53d8\u9633\u6027\u7684 NSCLC\u60a3\u8005\u672f\u540e\u901a\u5e38\u9700\u8981\u63a5\u53d72~3\u5e74\u7684EGFR-TKIs\u8f85\u52a9\u6cbb\u7597\u3002\u76ee\u524d\u4ec5\u6709\u57c3\u514b\u66ff\u5c3c\u4e0e\u5965\u5e0c\u66ff\u5c3c\u83b7\u6279\u4e86EGFR\u654f\u611f\u7a81\u53d8\u9633\u6027NSCLC\u672f\u540e\u8f85\u52a9\u6cbb\u7597\u7684\u9002\u5e94\u8bc1\uff0c\u4e14\u4ec5\u6709\u57c3\u514b\u66ff\u5c3c\u7684\u8f85\u52a9\u6cbb\u7597\u9002\u5e94\u8bc1\u7eb3\u5165\u533b\u4fdd\u3002\u56e0\u6b64\uff0c\u5728\u63a5\u53d72~3\u5e74EGFR-TKIs\u8f85\u52a9\u6cbb\u7597\u7684\u524d\u63d0\u4e0b\uff0c\u5efa\u8bae\u5728\u7597\u6548\u786e\u5207\u7684\u540c\u65f6\uff0c\u5e94\u4f18\u5148\u9009\u62e9\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u597d\u548c\u53ef\u53ca\u6027\u597d\u7684\u836f\u7269\u3002 2023\u7248CSCO\u6307\u5357\u6307\u51fa\uff1a\u9488\u5bf9II\u671f\u60a3\u8005\uff0c\u63a5\u53d7\u6839\u6cbb\u6027\u624b\u672f\u4e14\u672f\u540e\u68c0\u6d4b\u4e3aEGFR\u654f\u611f\u7a81\u53d8\u9633\u6027\uff0cI\u7ea7\u63a8\u8350\u672f\u540e\u5965\u5e0c\u66ff\u5c3c\uff08\u8f85\u52a9\u5316\u7597\u540e\uff09\u6216\u57c3\u514b\u66ff\u5c3c\u8f85\u52a9\u6cbb\u7597\uff1b\u9488\u5bf9III\u671f\u60a3\u8005\uff0c\u6839\u6cbb\u6027\u624b\u672f\u4e14\u672f\u540e\u75c5\u7406\u68c0\u6d4b\u4e3a EGFR\u654f\u611f\u7a81\u53d8\u578b\uff0cI\u7ea7\u63a8\u8350\u5965\u5e0c\u66ff\u5c3c\uff08\u5316\u7597\u540e\uff09\u6216\u57c3\u514b\u66ff\u5c3c\u8f85\u52a9\u6cbb\u7597\uff0cII\u7ea7\u63a8\u8350\u5409\u975e\u66ff\u5c3c\u6216\u5384\u6d1b\u66ff\u5c3c\u8f85\u52a9\u6cbb\u7597\uff081B\u7c7b\uff09\u3002CSCO\u6307\u5357\u672a\u63a8\u8350IB\u671f\u60a3\u8005\u8fdb\u884cEGFR-TKIs\u8f85\u52a9\u9776\u5411\u6cbb\u7597\uff0c\u7ed9\u51fa\u7684\u89e3\u91ca\u4e3a\uff1aADAURA\u7814\u7a76\u7eb3\u5165\u4e86IB\u671f\u60a3\u8005\uff0c\u4f46\u7531\u4e8e\u5176\u5c5e\u4e8e\u4e9a\u7ec4\u5206\u6790,\u4e14\u7814\u7a76\u91c7\u7528\u7684\u5206\u671f\u4e3a\u7b2c7\u7248\u5206\u671f\uff0c\u6545\u672c\u6307\u5357\u6682\u4e0d\u5c06\u5965\u5e0c\u66ff\u5c3c\u52a0\u5165IB\u671f NSCLC\u60a3\u8005\u672f\u540e\u8f85\u52a9\u6cbb\u7597\u7684I\u7ea7\u63a8\u8350\u3002 \u25b22023\u7248CSCO\u6307\u5357\u63a8\u8350\u7684EGFR\u654f\u611f\u7a81\u53d8\u672f\u540e\u8f85\u52a9\u6cbb\u7597\u65b9\u6848 EGFR-TKIs\u672f\u540e\u8f85\u52a9\u6cbb\u7597\u7684\u65f6\u95f4 \u300a2021\u7248\u6307\u5357\u300b\u6307\u51fa\uff1a\u533b\u751f\u6839\u636e\u60a3\u8005\u672f\u540e\u4f53\u80fd\u72b6\u51b5\u6062\u590d\u60c5\u51b5\u51b3\u5b9a\u542f\u52a8EGFR-TKI\u8f85\u52a9\u6cbb\u7597\u7684\u65f6\u95f4\uff0c\u6700\u665a\u4e0d\u8d85\u8fc7\u672f\u540e10\u5468\uff081\u7c7b\u8bc1\u636e\uff0c\u63a8\u8350\uff09\u3002\u5bf9\u4e8e\u63a5\u53d7\u8fc7\u8f85\u52a9\u5316\u7597\u7684EGFR\u7a81\u53d8\u9633\u6027\u60a3\u8005\uff0c\u53ef\u7ee7\u7eed\u63a5\u53d7\u7b2c\u4e09\u4ee3EGFR-TKI \u5965\u5e0c\u66ff\u5c3c\u8f85\u52a9\u6cbb\u7597\uff0c\u5f00\u59cb\u5965\u5e0c\u66ff\u5c3c\u8f85\u52a9\u6cbb\u7597\u7684\u65f6\u95f4\u901a\u5e38\u4e0d\u665a\u4e8e\u672f\u540e26\u5468\uff081\u7c7b\u8bc1\u636e\uff0c\u63a8\u8350)\u3002\u672f\u540eEGFR-TKI\u8f85\u52a9\u6cbb\u7597\u7684\u65f6\u95f4\u5e94\u4e0d\u5c11\u4e8e2\u5e74\uff081\u7c7b\u8bc1\u636e\uff0c\u63a8\u8350\uff09\u3002\u300a\u57c3\u514b\u66ff\u5c3c\u5171\u8bc6\u300b\u63a8\u8350EGFR\u654f\u611f\u7a81\u53d8\u7684II~IIIA\u671fNSCLC\u60a3\u8005\u81f3\u5c11\u63a5\u53d72\u5e74\u7684\u57c3\u514b\u66ff\u5c3c\u672f\u540e\u8f85\u52a9\u6cbb\u7597\u3002FDA\u7248\u548cNMPA\u7248\u8bf4\u660e\u4e66\u5747\u6307\u51fa\uff0c\u5965\u5e0c\u66ff\u5c3c\u7528\u4f5c\u672f\u540e\u8f85\u52a9\u836f\u7269\uff0c\u60a3\u8005\u5e94\u6301\u7eed\u63a5\u53d7\u6cbb\u7597\uff0c\u76f4\u81f3\u75be\u75c5\u590d\u53d1\u6216\u51fa\u73b0\u4e0d\u80fd\u8010\u53d7\u7684\u6bd2\u6027\u6216\u6cbb\u7597\u8fbe3\u5e74\u3002\u25b2FDA\u548cNMPA\u8bf4\u660e\u4e66\u4e2d\u5965\u5e0c\u66ff\u5c3c\u8f85\u52a9\u6cbb\u7597\u65f6\u95f4 \u300a2021\u7248\u6307\u5357\u300b\u6307\u51fa\uff1a\u5728\u4f7f\u7528EGFR-TKI\u8fdb\u884c\u8f85\u52a9\u6cbb\u7597\u65f6\uff0c\u65e2\u53ef\u4ee5\u4f7f\u7528EGFR-TKI\u5355\u836f\uff0c\u4ea6\u53ef\u91c7\u53d6\u8f85\u52a9\u5316\u7597\u5e8f\u8d2fEGFR-TKI\u7684\u6cbb\u7597\u6a21\u5f0f\uff08\u63a8\u8350\uff09\u3002\u4e34\u5e8a\u533b\u751f\u53ef\u4ee5\u6839\u636e\u60a3\u8005\u7684\u98ce\u9669\u3001\u4f53\u80fd\u72b6\u51b5\u548c\u4e2a\u4eba\u610f\u613f\u9009\u62e9\u6700\u5408\u9002\u7684\u8f85\u52a9\u9776\u5411\u6cbb\u7597\u6a21\u5f0f\uff08\u4e00\u81f4\u63a8\u8350\uff09\u3002 EGFR-TKIs\u672f\u540e\u8f85\u52a9\u6cbb\u7597\u7684\u7528\u836f\u4eba\u7fa4 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2021, 101(16):11.DOI:10.3760\/cma.j.cn112137-20210210-00406. [2]\u4e2d\u56fd\u533b\u7597\u4fdd\u5065\u56fd\u9645\u4ea4\u6d41\u4fc3\u8fdb\u4f1a\uff0c\u5e7f\u4e1c\u7701\u80f8\u90e8\u75be\u75c5\u5b66\u4f1a. \u57c3\u514b\u66ff\u5c3c\u672f\u540e\u8f85\u52a9\u6cbb\u7597\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u4e13\u5bb6\u5171\u8bc6. \u4e2d\u534e\u80bf\u7624\u6742\u5fd7\uff0c2023\uff0c45(01):31-38. DOI:10.3760\/cma.j.cn112152-20221028-00726 [3]2023\u975e\u5c0f\u7ec6\u80de\u80ba\u764cCSCO\u6307\u5357 [4]2023V4\u7248\u975e\u5c0f\u7ec6\u80de\u80ba\u764cNCCN\u6307\u5357 [5]Passaro A, Mok TSK, Attili I, Wu YL, Tsuboi M, de Marinis F, Peters S. Adjuvant Treatments for Surgically Resected Non-Small Cell Lung Cancer Harboring EGFR Mutations: A Review. JAMA Oncol. 2023 Aug 1;9(8):1124-1131. doi: 10.1001\/jamaoncol.2023.0459. [6]Masahiro Tsuboi, M.D., Roy S. Herbst, M.D., Ph.D.et al. Overall Survival with Osimertinib in Resected EGFR-Mutated NSCLC. June 4, 2023,NEJM.DOI: 10.1056\/NEJMoa2304594 [7]Herbst RS, Wu YL, John T, et al. Adjuvant Osimertinib for Resected EGFR-Mutated Stage IB-IIIA Non-Small-Cell Lung Cancer: Updated Results From the Phase III Randomized ADAURA Trial. J Clin Oncol. 2023 Jan 31:JCO2202186. doi: 10.1200\/JCO.22.02186. Epub ahead of print. 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