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PTGER4+SHOX2\u8054\u5408\u7532\u57fa\u5316\u68c0\u6d4b\u5728\u4e09\u9879\u72ec\u7acb\u7814\u7a76\u7684AUC\u5206\u6790\uff1aA\uff1a\u7814\u7a761\uff08AUC=0.98\uff09\uff1bB\uff1a\u7814\u7a762\uff08AUC=0.91\uff09\uff1bC\uff1a\u7814\u7a763\uff08AUC=0.95\uff093SHOX2+PTGER4\u6590\u7ef4\u6b23\u00ae\uff08SHOX2+PTGER4\uff09\u662f\u4e00\u79cd\u7528\u4e8e\u80ba\u764c\u65e9\u671f\u8bca\u65ad\u7684\u975e\u4fb5\u5165\u6027\u68c0\u6d4b\u4ea7\u54c1\uff0c\u901a\u8fc7\u68c0\u6d4b\u5916\u5468\u8840\u6837\u672c\u4e2d\u6e38\u79bbDNA\uff08cfDNA\uff09\u7684SHOX2\u57fa\u56e0\u548cPTGER4\u57fa\u56e0\u7684\u7532\u57fa\u5316\u72b6\u6001\uff0c\u5bf9\u53d7\u68c0\u8005\u53d1\u751f\u80ba\u764c\u7684\u6f5c\u5728\u98ce\u9669\u8fdb\u884c\u8bc4\u4f30\u3002\u8be5\u68c0\u6d4b\u53ef\u4f5c\u4e3a\u7591\u4f3c\u80ba\u764c\u3001\u6027\u8d28\u4e0d\u660e\u7684\u7ed3\u8282\u6216\u80ba\u764c\u9ad8\u5371\u4eba\u7fa4\u7b49\u7684\u8f85\u52a9\u8bca\u65ad\u65b9\u6cd5\u3002\u6590\u7ef4\u6b23\u00ae\u8bd5\u5242\u76d2\u57fa\u4e8e\u5168\u56fd3\u5bb6\u4e09\u7532\u533b\u9662\uff08\u5317\u4eac\u6d77\u6dc0\u533b\u9662\u3001\u5f90\u5dde\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u533b\u9662\u7b49\uff09\u76841700\u4f59\u4f8b\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e\u9a8c\u8bc1\uff0c\u83b7\u591a\u9879\u53d1\u660e\u4e13\u5229\u6388\u6743\uff08\u4e13\u5229\u53f7\uff1a202011531425.7\u3001202410730259.5\uff09\u3002\u540c\u65f6\uff0c\u6590\u7ef4\u6b23\u00ae\u4ee5\u5176\u53ef\u9760\u7684\u4e34\u5e8a\u6570\u636e\u548c\u68c0\u6d4b\u6280\u672f\u4e3a\u652f\u6491\uff0c\u83b7\u5f97\u80bf\u7624\u65e9\u7b5b\u884c\u4e1a\u8ba4\u53ef\u3002\u57282024\u5e74\u201c\u7b2c\u4e09\u5c4a\u80bf\u7624\u7cbe\u51c6\u533b\u7597\u4e0e\u6db2\u4f53\u6d3b\u68c0\u884c\u4e1a\u9ad8\u5cf0\u8bba\u575b\u201d\u4e0a\uff0c\u6590\u7ef4\u6b23\u00ae\u9996\u6b21\u516c\u5f00\u53d1\u5e03\u4e34\u5e8a\u6570\u636e\uff0c\u5f15\u53d1\u5e7f\u6cdb\u5173\u6ce8\u3002\u540e\u7eed\u5b89\u9f99\u57fa\u56e0\u53d7\u9080\u53c2\u52a0\u300a\u6db2\u4f53\u6d3b\u68c0\u80bf\u7624\u65e9\u7b5b\u6280\u672f\u670d\u52a1\u89c4\u8303\u300b\u56e2\u4f53\u6807\u51c6\u7f16\u5199\u3002\u57282025\u5e74\u80bf\u7624\u65e9\u7b5b\u65b0\u6280\u672f\u8bba\u575b\u4e2d\uff0c\u56fd\u5bb6\u764c\u75c7\u4e2d\u5fc3\u5f20\u51ef\u6559\u6388\u5728\u4e3b\u8bba\u575b\u53d1\u8868\u91cd\u78c5\u6f14\u8bb2\uff0c\u4ee5\u6590\u7ef4\u6b23\u00ae\u4e3a\u6838\u5fc3\u6848\u4f8b\uff0c\u63ed\u793a\u7532\u57fa\u5316\u6280\u672f\u7684\u9769\u547d\u6027\u4ef7\u503c\u3002\u6590\u7ef4\u6b23\u00ae\u4ea7\u54c1\u7684\u76f8\u5173\u4e13\u5229\u8d44\u6599Lung 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[1]\u4e2d\u534e\u533b\u5b66\u4f1a\u653e\u5c04\u5b66\u5206\u4f1a\u5fc3\u80f8\u5b66\u7ec4. \u4f4e\u5242\u91cf\u87ba\u65cbCT\u80ba\u764c\u7b5b\u67e5\u4e13\u5bb6\u5171\u8bc6. \u4e2d\u534e\u653e\u5c04\u5b66\u6742\u5fd7. [2]2023\u4e2d\u56fd\u80ba\u764c\u65e9\u7b5b\u65e9\u8bca\u884c\u4e1a\u84dd\u76ae\u4e66. [3]\u4e2d\u534e\u533b\u5b66\u4f1a\u547c\u5438\u75c5\u5b66\u5206\u4f1a. \u65e9\u671f\u80ba\u764c\u8bca\u65ad\u4e2d\u56fd\u4e13\u5bb6\u5171\u8bc6\uff082023\u5e74\u7248\uff09[J]. \u4e2d\u534e\u7ed3\u6838\u548c\u547c\u5438\u6742\u5fd7\uff0c2023\uff0c46(1):1-18. [4]\u4e2d\u56fd\u6297\u764c\u534f\u4f1a\u80bf\u7624\u6807\u5fd7\u4e13\u4e1a\u59d4\u5458\u4f1a. \u80bf\u7624DNA\u7532\u57fa\u5316\u6807\u5fd7\u7269\u68c0\u6d4b\u53ca\u4e34\u5e8a\u5e94\u7528\u4e13\u5bb6\u5171\u8bc6\uff082024\u7248\uff09[J]. \u4e2d\u56fd\u764c\u75c7\u9632\u6cbb\u6742\u5fd7\uff0c2024\uff0c16(2):129-142. [5]Schmidt B , Liebenberg V , Dietrich D , et al. SHOX2 DNA methylation is a biomarker for the diagnosis of lung cancer based on bronchial aspirates. BMC Cancer\uff0c2010\uff0c(10):600-608. [6]Kneip C , Schmidt B , Seegebarth A , et al. SHOX2 DNA methylation is a biomarker for the diagnosis of lung cancer in plasma. Journal of Thoracic Oncology\uff0c2011\uff0c6(10):1732-1638. [7]\u5f20\u946b\u96ef\uff0c\u5f6d\u8bd7\u7487\u7b49. DNA\u7532\u57fa\u5316\u68c0\u6d4b\u5728\u80ba\u764c\u65e9\u671f\u8bca\u65ad\u548c\u9884\u540e\u5224\u65ad\u4e2d\u7684\u5e94\u7528. \u4e2d\u534e\u68c0\u9a8c\u533b\u5b66\u6742\u5fd7\uff0c2024\uff0c47(4):371-378. [8]G Weiss, et al. Validationof the SHOX2\/PTGER4 DNA Methylation Marker Panel for Plasma-BasedDiscrimination between Patients with Malignant and Nonmalignant Lung Disease. Journal of Thoracic Oncology\uff0c2017\uff0c12(1):77-84. [9] \u521d\u971e, \u8d75\u4f1f,\u738b\u4fdd\u5065. \u8840\u6d46\u65e0\u7ec6\u80deDNA\u4e2dSHOX2\u548cPTGER4\u57fa\u56e0\u7532\u57fa\u5316\u68c0\u6d4b\u6709\u52a9\u4e8e\u80ba\u7ed3\u8282\u60a3\u8005\u7684\u9274\u522b\u8bca\u65ad[J]. \u7ec6\u80de\u4e0e\u5206\u5b50\u514d\u75ab\u5b66\u6742\u5fd7\uff0c2019\uff0c(4):357-361. \u5b89\u9f99\u57fa\u56e0\u5b89\u9f99\u57fa\u56e0\u6210\u7acb\u4e8e2016\u5e74\uff0c\u79c9\u6301\u4ee5\u201c\u5e2e\u52a9\u764c\u75c7\u60a3\u8005\u77e5\u9053\u66f4\u65e9\uff0c\u611f\u89c9\u66f4\u8212\u670d\uff0c\u751f\u6d3b\u66f4\u957f\u4e45\u201d\u4e3a\u4f7f\u547d\uff0c\u7acb\u8db3\u4e34\u5e8a\u9700\u6c42\uff0c\u4e13\u6ce8\u5f00\u53d1\u80bf\u7624\u65e9\u7b5b\u65e9\u8bca\u8bd5\u5242\u548c\u667a\u80fd\u5316\u80bf\u7624\u57fa\u56e0\u7532\u57fa\u5316\u68c0\u6d4b\u5e73\u53f0\uff0c\u65e8\u5728\u4e3a\u4e34\u5e8a\u533b\u751f\u63d0\u4f9b\u66f4\u7cbe\u51c6\u7684\u4e34\u5e8a\u51b3\u7b56\u4f9d\u636e\u3002 \u516c\u53f8\u62e5\u6709\u591a\u4e2a\u56fd\u5185\u9996\u521b\u764c\u75c7\u65e9\u7b5b\u65e9\u8bca\u4ea7\u54c1\uff0c\u76ee\u524d\u5df2\u63a8\u51fa\u72ec\u5bb6\u201cAI+\u5206\u5b50\u6280\u672f+\u8bbe\u5907\u5e73\u53f0\u201d\u6838\u5fc3\u4e13\u5229\u548c\u4ea7\u54c1\u2014\u2014\u6590\u7ef4\u6b23\u00ae\u65e9\u671f\u80ba\u764c\u57fa\u56e0\u7532\u57fa\u5316\u68c0\u6d4b\u8bd5\u5242\u76d2\u548c\u667a\u80fd\u5316\u80bf\u7624\u57fa\u56e0\u7532\u57fa\u5316\u68c0\u6d4b\u7cfb\u7edf\u3002 \u540c\u65f6\u516c\u53f8\u6210\u529f\u5f00\u53d1\u51faOmegaSeq\u6269\u589e\u5b50\u6355\u83b7\u5efa\u5e93\u3001\u591a\u91cd\u5f15\u7269\/\u63a2\u9488\u53cc\u963b\u65adctDNA\u7532\u57fa\u5316\u68c0\u6d4b\u4ee5\u53ca\u81ea\u52a8\u5316\u6570\u636e\u5206\u6790\u7b49\u591a\u9879\u80bf\u7624\u7cbe\u51c6\u68c0\u6d4b\u5206\u6790\u6280\u672f\uff0c\u642d\u5efaPCR\u3001\u6570\u5b57PCR\u3001\u4e00\u4ee3\u6d4b\u5e8f\u3001\u4e8c\u4ee3\u6d4b\u5e8f\u7b49\u5728\u5185\u7684\u591a\u79cd\u5206\u5b50\u8bca\u65ad\u5e73\u53f0\uff0c\u4e3a\u4e34\u5e8a\u63d0\u4f9b\u80bf\u7624\u514d\u75ab\u3001\u9776\u5411\u7528\u836f\u6307\u5bfc\u3001\u65e9\u671f\u7b5b\u67e5\u3001\u9884\u540e\u5224\u65ad\u53ca\u9057\u4f20\u6027\u80bf\u7624\u7b5b\u67e5\u7b49\u5168\u5468\u671f\u533b\u5b66\u8bca\u65ad\u670d\u52a1\u3002\u516c\u53f8\u4ee5\u6ee1\u5206\u6210\u7ee9\u901a\u8fc7\u591a\u9879\u5168\u56fd\u4e34\u5e8a\u68c0\u9a8c\u5ba4\u95f4\u8d28\u91cf\u8bc4\u4ef7\uff0c\u5e76\u83b7\u5f97\u201c\u56fd\u5bb6\u9ad8\u65b0\u6280\u672f\u4f01\u4e1a\u201d\u3001\u201c\u4e2d\u56fd\u9690\u5f62\u72ec\u89d2\u517d500\u5f3a\u201d\u3001\u201c\u5b89\u5fbd\u7701\u6218\u7565\u65b0\u5174\u4ea7\u4e1a\u96c6\u805a\u53d1\u5c55\u57fa\u5730\u201d\u3001\u201c\u5b89\u5fbd\u7701\u9ad8\u5c42\u6b21\u79d1\u6280\u4eba\u624d\u56e2\u961f\u201d\u3001\u201c\u5b89\u5fbd\u7701\u4f01\u4e1a\u7814\u53d1\u4e2d\u5fc3\u201d\u7b49\u591a\u9879\u8363\u8a89\u79f0\u53f7\u3002\u5b89\u9f99\u57fa\u56e0\u5b89\u9f99\u533b\u5b66\u89c9\u5f97\u5185\u5bb9\u8fd8\u4e0d\u9519\u7684\u8bdd\uff0c\u7ed9\u6211\u70b9\u4e2a\u201c\u5728\u770b\u201d\u5457","source_url":"https:\/\/www.anlongen.com\/Article\/detail\/id\/188.html","alternate_url":"https:\/\/www.anlongen.com\/Article\/aiFeed\/id\/188.html","updated_at":"2025-11-13T00:00:00+08:00"}}